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But, bad news for them is excellent news for ACXP. Still, expect PFE, SNY, and SMMT to have uphill battles. Further, all three appear to be scrambling to save its programs, knowing that the potential market in dollar terms to treat CDI is well worth the fight. In fact, all three had topline misses, which is often a death knell for a clinical trial. Last Tuesday, Pfizer joined two other companies that showed less than impressive data from their C. Not only that, from an investors’ perspective, ACXP has never looked more ready to generate significant gains in the near term.
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Thus, with ACXP powering through its Phase 2b trial supported with best-in-class data and an expected ticket to enter Phase 3, the ACXP investment proposition at current levels is frankly getting too big to ignore. In fact, treatment cycles can run as little as ten days, with follow-up done at 30 days. ACXP could move through its Phase2b trial quickly, with enrollment already underway and the duration of treatment relatively short. And here’s more excellent news, impressive trial data from its Ph2a trial pushed the Trial Oversight Committee and the Scientific Advisory Board, to allow for an early termination of its Phase 2a trial and advance straight into a Phase 2b study after data on just ten patients showed 100% cure rate and 100% sustained cure after follow-up when treating patients with C. Not only that, ACXP has a running start to extend its competitive distance in its targeted indication, with Phase 2a data already suggesting ibezapolstat could become the go-to drug to treat CDI, a debilitating infection that affects hundreds of thousands of patients per year. In addition to ACXP seeing the potential competitive landscape shrink, its Phase 2 trial evaluating ibezapolstat to treat CDI is showing more than an ability to earn front-line status it may also change for the better an antibiotics drug landscape that hasn’t seen meaningful improvements in more than three decades.
Thus, the recent beat down in small-cap biotech, ACXP included, has created more than an attractive investment proposition it exposed a compelling one.Īctually, the proposition gets better. But, for ACXP, the misfortune of others can lead to a windfall of opportunities and more importantly, positions them as one of the few, if only, known clinical stage companies without a blemish on its trial record to treat the debilitating infection. Their miss, by the way, follows both Sanofi (NYSE: SNY) and Summit Therapeutics (NYSE: SMMT), which also posted disappointing topline results in their missions to tap into themore than $1.5 billion CDI treatment market.
That’s because another Big Pharma player, Pfizer (NYSE: PFE), missed its trial primary endpoint in its CLOVER Phase 3 trial targeting treatment for C.
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